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The Universal Tuffleization Plan was a plan organized by Baby with the goal of annihilating all non-Tuffle lifeforms in Universe 7. It began under the guise of the "Total Galaxy Conquest Operation" - Dr. Myuu's desire of conquering the entirety of Universe 7 and to convert all of its organisms into Machine Mutants loyal to him.
Total Galaxy Conquest Operation
Myuu was apparently a native M-2 resident who, after meeting the Tuffle King's parasitic clone in Age 740, had managed to convert himself into a Machine Mutant and set about constructing a Machine Mutant army. After his army was sufficient enough to accomplish his first goal, he attacked his homeworld and caused its natives' extinction.
After a while, between Age 760 to Age 770, Myuu had acquired the assistance of an alien who chose to be converted into a Machine Mutant. This individual would later become known as General Rilldo.
Rilldo was tasked by Myuu (who had been brainwashed by Baby) to go on a hunt for the Black Star Dragon Balls without mentioning it was for the resurrection of the Tuffles. Myuu had also created the Sigma Force to aid Rilldo as his top-men.
Myuu and Dolltaki had plotted the scheme for aiding Baby's power growth by creating the fake Planet Luud's cult under Cardinal Mutchy Mutchy's guise as the priest for the fake deity Luud, whose sole purpose was to fuel Baby with the energies he had gathered within him (the believers were turned into dolls by Mutchy's whip and were fed to Luud's core).
After all of the aforementioned villains were defeated, Myuu had witnessed Baby's revival on Myuu's Planet and admitted that all he ever wanted to do was not to convert the universe into Machine Mutants, but to have them subdued through Tuffleization to Baby, who ultimately kills Myuu for his failures against the Dragon Team and sets out on a genocidal campaign against all non-Tuffle lifeforms.
Universal Tuffleization Plan
Baby quickly takes over Earth by infecting almost all of its inhabitants with Tuffle Parasites and taking Vegeta's body for his own, becoming an incredibly powerful warrior in the process. Kibito Kai manages to eradicate the Tuffle Parasites using the Sacred Water, while Super Saiyan 4 Goku drives Baby out of Vegeta's body, before proceeding to obliterate him by propelling him into the sun with a 10x Kamehameha.