"The REAL FIGHT starts now!"
The Supreme Kamehameha is fired with far more force and intensity than the Imperfect Instinct Kamehameha. Goku does not manipulate the Supreme Kamehameha's energy, unlike its predecessor, though it is extremely likely that Goku can do so.
Usage and Power
In the anime, in the completed form of Ultra Instinct, Goku uses the Supreme Kamehameha two times against Jiren. While the Supreme Kamehameha was initially overpowered by Jiren's Heatwave Magnetron with his Super Full Power, upon being angered by Jiren attempting to kill Goku's friends the Supreme Kamehameha grew in power to the point that it was able to knock Jiren hard into the stage rubble, leaving the Pride Trooper severely injured and briefly incapacitated, though the strain of Ultra Instinct's extreme concentration drains Goku of his remaining focus and forces him out of the form.
In the manga, Goku uses the Supreme Kamehameha in order to shoot Jiren through the stage and out the bottom of it, almost eliminating him.
In the anime Goku uses this technique to destroy Kamioren.
Video Game Appearances
The Supreme Kamehameha is named and appears as Ultra Instinct Goku's super attack in Dragon Ball Z: Dokkan Battle. It appears under the name Ultimate Instinct Kamehameha (究極極意のかめはめ波 Kyūkyoku Gokui no Kamehameha) in Dragon Ball Heroes.